DYNAMICS OF THE IMMUNE STATUS OF WOMEN IN THE TREATMENT OF HUMAN PAPILLOMA VIRUS (HPV) OF THE CERVIX

Abstract

HPV in the process of infection affects the basal layers of immature skin cells and mucous membranes, which are then a constant source of infection of epithelial cells. An infected cell may contain from 10 to 200 episis in the cytoplasm of the cells of the basal layer for some time. Infection is facilitated by microtrauma (bacterial microdamage, mechanical trauma, etc.) of the skin and mucous membranes. The most vulnerable area is the mucous membrane in the cervical transformation zone - the transition site of the stratified squamous into the cylindrical epithelium. For infection, a single viral particle is enough to trigger an infectious process. The time elapsing from the time of initial infection to clinical manifestations can vary and is determined by the titer of the infectious particles. A low titer leads to the formation of a latent infection (carriage). It is known that the activation of latent infection is possible only against the background of a decrease in immunity.