EFFECT OF FLAVONOIDS SAFORAFLAVONOLOSIDE AND NARCISSIN ON THE FUNCTIONAL STATE OF RAT HEART MITOCHONDRIA IN AN EXPERIMENTAL MODEL OF ISCHEMIA

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Published Jul 31, 2022
https://doi.org/10.17605/OSF.IO/WDPN5
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Vol. 8 No. 7 (2022): Journalnx

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E.I. Mirzaolimov
Namangangan State University, Faculty of Medicine, 160119, Namangan, Boburshoh Str.161
M.K. Pozilov
National University of Uzbekistan named after Mirzo Ulugbek, Faculty of Biology, 100174, Tashkent, st. Universitetskaya 4
B. S. Ohundedayev
Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, ul. Mirzo Ulugbeka, 77, Tashkent, 100170, (Uzbekistan)
S. Z. Nishanbayev
Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, ul. Mirzo Ulugbeka, 77, Tashkent, 100170, (Uzbekistan
G. R. Abdullayev
Namangangan State University, Faculty of Medicine, 160119, Namangan, Boburshoh str. 161
M. M. Mamajanov
Namangangan State University, Faculty of Medicine, 160119, Namangan, Boburshoh str. 161

Abstract

In this research it has been investigated the effect of sophoraflavonoloside isolated from Crocus sativus L. plant, narcissine flavonoid isolated from Alhagi canescens (Regel) B. Keller & Shap plant on functional disorders of rat cardiac mitochondria under conditions of experimental ischemia. Flavonoids were extracted from plant materials using alcohol-water (70%). They were re-extracted with organic solvents and separated into fractions, and pure glycosides of flavonoids were isolated from the ethyl acetate fraction using column chromatography. Using differential centrifugation, mitochondria were isolated from the hearts of healthy and ischemic rats. Animals with ischemia received orally narcissine 10 mg / kg and saforaflovonoloside (SFL) 10 mg / kg for 7 days. They have been shown to restore the swelling of the mitochondria of the heart of ischemic rats, lipid peroxidation (LPO), and the formation of malondialdehyde (MDA).

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E.I. Mirzaolimov, M.K. Pozilov, B. S. Ohundedayev, S. Z. Nishanbayev, G. R. Abdullayev, & M. M. Mamajanov. (2022). EFFECT OF FLAVONOIDS SAFORAFLAVONOLOSIDE AND NARCISSIN ON THE FUNCTIONAL STATE OF RAT HEART MITOCHONDRIA IN AN EXPERIMENTAL MODEL OF ISCHEMIA. JournalNX - A Multidisciplinary Peer Reviewed Journal, 8(7), 110–117. https://doi.org/10.17605/OSF.IO/WDPN5