EFFECTS OF PAPAVERINE AND “VETVITTELS” LLC COMMERCIAL DIETARY SUPPLEMENTS ON BLOOD GLUCOSE AND BODY WEIGHT IN OBESE DOGS

Abstract

Our experiments showed that papaverine inhibits sugar absorption in vivo as well as in vitro. The inhibitory effect of papaverine on glucose absorption was demonstrated in experiments on three species – rats, guinea pigs and dogs and it can be observed in different types of cells (enterocytes and cardiocytes). It blocks the absorption of sugar both in healthy and diabetic animals. Oral administration of papaverine significantly reduced blood sugar level but after an hour blood sugar level showed tendency to come back to the initial levels that were characteristic for these diabetic dogs. Dietary supplement D-28 has proven to be quite effective in reducing body weight in dogs. For a month, dogs with initial overweight lost on average more than 2 kg (12.8±0.4), that is a very good result for their size.