ACCORDING TO THE IMMUNOLOGICAL PARAMETERS OF PEOPLE WITH FAMILY BRONCHIAL ASTHMA IN THE UZBEK POPULATION DIFFERENTIAL-DIAGNOSTIC AND PROGNOSTIC CRITERIA OF THE DISEASE (

Abstract

The article examines the spectrum of immunoglobulin, anti-inflammatory and increasing cytokines in blood serum in familial bronchial asthma, as well as the nature of the pathogenetic and clinical types that determine the course of the disease. 346 relatives from 49 families with bronchial asthma were examined. At the same time, total IgE, IL-6 and interferon-γ were tested in serum using the IFA method using the Vector-Best test system. Serum levels of total IgE, IL-6 and interferon-g detected in the blood serum of patients with familial bronchial asthma were analyzed for pathogenetic types of AD disease, disease severity, medical history and disease control. It has been shown that in familial bronchial asthma, an increase in total serum IgE, IL-6 and a decrease in interferon-g are differential diagnostic markers of disease progression, allergic type, accelerated disease progression and uncontrolled disease.