SYNTHESIS OF 2-CHLORO-N-(3-HYDROXYPHENYL) ACETAMIDE AND 2-CHLORO-N-(4-HYDROXYPHENYL) ACETAMIDE AND STUDY OF THEIR ANTIMICROBIAL ACTIVITY

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Published Jan 13, 2021
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M.S. Yusufov
National University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, University str, 4
T.S. Kholikov
National University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, University str, 4
T.S. Kholikov
National University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, University str, 4
S.A. Sasmakov
Acad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,
F.B. Eshboev
Acad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,
J.M. Abdurakhmanov
Acad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,
Sh.S. Azimova
Acad. S.Yu. Yunusov Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek str, 77,

Abstract

In this work, the results of chloroacetylation of m- and p-aminophenols in the presence of acetic acid, acetonitrile and tetrahydrofuran as a solvent were presented. Methods of purification of the obtained substances were described. The structure of synthesized substances is established by methods of IR, PMR, mass spectroscopy. The antibacterial and antifungal activities of these compounds were investigated. The results of the screening revealed that the compounds showed the appreciable antibacterial activity against Gram-positive and Gram-negative bacteria, whereas compounds did not exhibit any potential antifungal activity.

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How to Cite
M.S. Yusufov, T.S. Kholikov, T.S. Kholikov, S.A. Sasmakov, F.B. Eshboev, J.M. Abdurakhmanov, & Sh.S. Azimova. (2021). SYNTHESIS OF 2-CHLORO-N-(3-HYDROXYPHENYL) ACETAMIDE AND 2-CHLORO-N-(4-HYDROXYPHENYL) ACETAMIDE AND STUDY OF THEIR ANTIMICROBIAL ACTIVITY . JournalNX - A Multidisciplinary Peer Reviewed Journal, 486–491. Retrieved from https://repo.journalnx.com/index.php/nx/article/view/467